This hotel is very close to a U Bahn station and from that station you can get anywhere in Berlin. The neighborhood itself is very quiet and is easily walkable to a lot of restaurants and shopping.
We were traveling with 4 people and this hotel was really great for us. The people at the front desk were extremely helpful and even let me practice my (probably terrible) German with them, even though it wasn't necessary. The breakfast was awesome (I love breakfasts in Germany so much - it's so much better than my sad breakfasts back at home) and the food was fresh and delicious.
About the only complaint we had was that the internet connection was pretty bad, but we are on holiday, get off the internet and go explore Berlin right? I would definitely recommend this hotel to anyone.