Great Hotel! My wife and I stayed at Hotel Sant'Anna over Easter weekend 2026. The staff was fantastic. They knew the area, suggested some do's and don'ts, and we most helpful when our flight home was canceled - rebooking us around the corner. The room was clean, everything worked, and was most comfortable. The breakfast area was clean, attendants were perfect, and the buffet had something for every taste. Location is 2.5 minutes from San Pietro. Great for a nighttime gelato, quick walk around the square, then home to rest. I would HIGHLY recommend this hotel for anyone staying in the Vatican area. The only negative was not under their control. The weather was unseasonably warm, but the hotel was not allowed to run the air conditioning due to government regulations. With that, we needed to open our windows overnight to get some cool air. The restaurants along the street have outside seating, and when they close, the restaurant staff is not very quiet as they drag their chairs and tables back inside, and conversing using "outside voices" along the way. It only lasted about 30 minutes, but after 11pm when you've been walking for 8 hours all day, you want quiet when you sleep. But, that was just because of the lack of being allowed to run AC. The one night we kept the windows closed, it was quiet and easy to sleep. This is not a complaint about the hotel. The warm weather was very welcome, and the noise was a small price to pay. :-)

Loved location

Great staff clean room We had a front room, which was a little noisy until around midnight lol AC could be a little cooler. But at night windows were open, cooled room off.

Air conditioner could be a little cooler

Great location, nice breakfast, helpful staff

Great room.

My room was epic with a window to the street Borgo Pio! Bravo!

Rooms were immaculate, staff were courteous, breakfast was wonderful.

Wonderful room and fantastic location.

Very hospitable front desk staff. Will be staying here from now on everytime Rome tugs at my heartstrings!

Hotel Sant ‘Anna is in a great location close to Vatican City, the metro, and many restaurants & tourist shops. We were comfortable and had space for our family of four. The hotel is nice, clean, quiet, and comfortable. The staff was friendly and helpful. The only downside was the annoyance of having to walk past the restaurants hawkers (with their high-pressure sales pitch to lure in you and others) who on the street in front of the hotel, but that was the trade-off for convenience.

Very friendly staff. Free breakfast with the stay.

Wonderful location, very helpful service and staff!

Extremely nice and helpful staff. Room was very quaint and great access to a lot of tourist spots within a mile. Room was cleaned every day. Highly recommend

All of the staffs were amazing. We stayed for 5 nights and no complaints at all. Breakfast was great. This is the hotel

This hotel is very quaint near everything to walk. The front desk was very nice and helpful and polite. Nice breakfast in the morning too. I would definitely stay here again.

From the moment we arrived atthe hotel until we left, our visit was nothing short of amazing. Walking distances to most every site and point of intrest!

Great location, amazing staff!

Great little hotel very near the Vatican. Very clean and typically Roman. Lovely.

The staff was outstanding. Very helpful and friendly. Location very walkable, close to Vatican and also short walk to subway, etc the room was comfortable and shower had good water pressure.