I really can't say too much about this hotel because I don't want it to be so popular. I can't get in it again , just kidding. It is a beautiful old hotel and when I say Old that's very pleasing. There are so many restaurants all around and the staff here are incredible. At night of course in Venice is extremely quiet, especially in this area. The hotel was a very short walk from the vaporetto dock and via the #1 vaporetto a short distance from the railway station. I stayed here three nights and only had one breakfast as it's just too much to do to sit although it was very good. The coffee is fantastic and the little bar adequate for a last-minute drink before calling it a night. Of course, if no one's there they close up early and that's OK, as here's so many bars or places to find a late night drink if that's necessary.
The area of course is extremely safe no worries. Our room had an incredible view of one of the churches. I had absolutely no fears of any safety, although there is a room safe, but we didn't use it.
This hotel is very close to shopping if you can afford it. This hotel is very close to Saint Marks Basilica, and the plaza.
I highly suggest you buy vaporetto pass for the number of days that you're on the islands as it may be easier to jump on and jump off a ferry instead of walking the great distance you will want to travel to explore. Walking from the train station to the hotel I could, but it's much easier by vaporetto. You will fall in love with the hotel..