You could not be any more central than staying here. The Aquarium is steps away and so are many cafes and restaurants. At first this had me worried about noise and parking, but the parking rate includes valet, which makes it super easy. And even though we stayed at street facing room by the elevator, we heard nothing in our room. The hotel is clean, the staff is friendly, I liked the refillable water bottles they offer.
The only thing I can think of that could be better is the restaurant service at the restaurant at the bottom floor of the hotel. Not sure how closely they are associated with the hotel, but they were definitely lacking in comparison to the hotel (no water refills, took forever to wave someone down for the bill).