Hotel Sant' Anna

What an amazing experience. The staff are friendly and helpful (great recommendations for dinner), the hotel is charming, the neighbourhood is interesting and walkable, and the location is great.

Loved this place and the character it had! We only stayed one night and wished we had more time. It’s located in a great location and close to the Vatican! Highly recommend!

A beautiful old building in a perfect location minutes from Vatican. A stone throw to many terrific restaurants and patios. Some of the friendliest staff we have experience in the EU. Highly recommend this property for an enjoyable stay in Rome

Excellent location

We booked same day and were lucky to find a room anywhere in Rome. Our VRBO cancelled and we needed a place for the night. The hotel staff was amazing, the room was clean and perfect. The hotel turned our horrible situation to wonderful. The hotel is in a great location with lots of shops and restaurants.

Very nice hotel, clean room

Great Hotel! My wife and I stayed at Hotel Sant'Anna over Easter weekend 2026. The staff was fantastic. They knew the area, suggested some do's and don'ts, and we most helpful when our flight home was canceled - rebooking us around the corner. The room was clean, everything worked, and was most comfortable. The breakfast area was clean, attendants were perfect, and the buffet had something for every taste. Location is 2.5 minutes from San Pietro. Great for a nighttime gelato, quick walk around the square, then home to rest. I would HIGHLY recommend this hotel for anyone staying in the Vatican area. The only negative was not under their control. The weather was unseasonably warm, but the hotel was not allowed to run the air conditioning due to government regulations. With that, we needed to open our windows overnight to get some cool air. The restaurants along the street have outside seating, and when they close, the restaurant staff is not very quiet as they drag their chairs and tables back inside, and conversing using "outside voices" along the way. It only lasted about 30 minutes, but after 11pm when you've been walking for 8 hours all day, you want quiet when you sleep. But, that was just because of the lack of being allowed to run AC. The one night we kept the windows closed, it was quiet and easy to sleep. This is not a complaint about the hotel. The warm weather was very welcome, and the noise was a small price to pay. :-)

Loved location

Great staff clean room We had a front room, which was a little noisy until around midnight lol AC could be a little cooler. But at night windows were open, cooled room off.

Air conditioner could be a little cooler

Great location, nice breakfast, helpful staff

Great room.

My room was epic with a window to the street Borgo Pio! Bravo!

Rooms were immaculate, staff were courteous, breakfast was wonderful.

Wonderful room and fantastic location.

Very hospitable front desk staff. Will be staying here from now on everytime Rome tugs at my heartstrings!

Hotel Sant ‘Anna is in a great location close to Vatican City, the metro, and many restaurants & tourist shops. We were comfortable and had space for our family of four. The hotel is nice, clean, quiet, and comfortable. The staff was friendly and helpful. The only downside was the annoyance of having to walk past the restaurants hawkers (with their high-pressure sales pitch to lure in you and others) who on the street in front of the hotel, but that was the trade-off for convenience.

Very friendly staff. Free breakfast with the stay.

Wonderful location, very helpful service and staff!

Extremely nice and helpful staff. Room was very quaint and great access to a lot of tourist spots within a mile. Room was cleaned every day. Highly recommend