Guyana is generally safe for tourists, but like any destination, it's important to exercise caution. Most visits are trouble-free, but petty crime can occur, especially in Georgetown. Stick to well-traveled areas, avoid displaying valuables, and use reputable tour operators for excursions. The country's interior is quite safe, and eco-lodges often have good security measures in place. Always check your government's travel advisories before your trip and consider getting travel insurance.

For travel to Guyana, it's recommended to be up-to-date on routine vaccinations such as MMR, DPT, and influenza. Additionally, hepatitis A and typhoid vaccinations are advised for most travelers. Depending on your activities and length of stay, you might also need vaccinations for hepatitis B, yellow fever, and malaria prophylaxis. Consult with a travel health specialist or your doctor at least 4-6 weeks before your trip to get personalized advice based on your medical history and travel plans.

The best time to visit Guyana is during the dry seasons, which typically run from February to April and from August to October. These periods offer more comfortable weather for outdoor activities and wildlife viewing. However, Guyana can be visited year-round, and the rainy seasons (May to July and November to January) can offer unique experiences, such as lush landscapes and impressive waterfalls. Keep in mind that some interior roads may become impassable during heavy rains.

Guyana's top attractions include the majestic Kaieteur Falls, one of the world's highest single-drop waterfalls; the pristine rainforests of Iwokrama, home to diverse wildlife; the Rupununi Savannah, known for its ranch stays and bird watching; Shell Beach, where sea turtles nest; and the historic sites of Georgetown, including St. George's Cathedral and the Stabroek Market. Nature lovers shouldn't miss the chance to spot unique wildlife like the harpy eagle, giant river otter, or black caiman in their natural habitats.

Transportation in Guyana varies depending on your destination. In Georgetown and other towns, taxis and minibuses are common. For travel between major towns, you can use long-distance buses or domestic flights. To reach remote interior locations, small aircraft, boats, and 4x4 vehicles are often necessary. Many tourists opt for organized tours that handle transportation logistics. If you're planning to explore independently, especially in the interior, it's advisable to hire a local guide or use a reputable tour operator due to limited infrastructure and challenging terrain.