Hotels in Cape Girardeau County

The four-story Hampton Inn is located in Cape Girardeau, off I-55 at Exit #96 (Route K/William Street) in Southeastern Missouri. Cape Girardeau is 100 miles south of St. Louis and 170 miles north of Memphis, TN. Our convenient location at the southeastern corner of I-55 & Route K is just 4.5 miles from downtown Cape Girardeau and 6 miles from Cape Girardeau Regional Airport. Southeast Missouri State University (4 miles), Show Me Center (4.5 miles), Isle of Capri Casino (4.5 miles), St. Francis Hospital (1 block) and Southeast Missouri Hospital (4 miles) are all easily accessible. In the hotel complex (easy walking distance) is the Plaza Conference Center, Red Lobster, Olive Garden, Popeyes Chicken, Panera Bread, Honey Baked Ham, Cracker Barrel, Texas Roadhouse and Bella Donna Salon. We are also very convenient for business travelers with access to Procter & Gamble (18 miles), Doctors Park Complex (1 block), Mondi (18 miles), Rubbermaid (9 miles) Southeast Missouri Regional Port Authority (6 miles) and Biokyowa (7 miles). Local attractions include Shawnee Park Sports Complex (3 miles), Mississippi River & Missouri Wall of Fame Mural (5 miles), Cape Splash Family Aquatic Center (3 miles), Westpark Mall (1 block), Lewis & Clark Red House Interpretive Center (5 miles), Historic Bollinger Mill (16 miles), Glenn House (4 miles), Fort D (4.5 miles), SEMO River Campus (4.5 miles), Arena Park (3 miles), Trail of Tears State Park (15 miles), Dalhousie Golf Course (4 miles), Bent Creek Golf Course (10 miles), Steele Crest Winery (9 miles) and River Ridge Winery (10 miles).

Located in Cape Girardeau, Courtyard by Marriott Cape Girardeau Downtown is within a 15-minute walk of Shawnee National Forest and eDen Spa & Salon. This hotel is 0.7 mi (1.1 km) from Isle Casino Cape Girardeau and 0.7 mi (1.2 km) from Southeast Missouri State University.

A stay at Comfort Suites Jackson-Cape Girardeau places you in the heart of Jackson, within a 5-minute drive of Cape Girardeau Conservation Nature Center and Saint Francis Healthcare System. This hotel is 6.7 mi (10.7 km) from Shawnee National Forest and 7 mi (11.2 km) from Mississippi River.

With a stay at Quality Inn in Cape Girardeau, you'll be within a 5-minute drive of Saint Francis Healthcare System and Cape Splash Family Aquatic Center. This hotel is 4.5 mi (7.2 km) from Shawnee National Forest and 4.8 mi (7.7 km) from Mississippi River.

With a stay at Auburn Place Hotel And Suites in Cape Girardeau, you'll be within a 5-minute drive of Saint Francis Medical Center and Saint Francis Healthcare System. This hotel is 4.3 mi (6.9 km) from Shawnee National Forest and 4.6 mi (7.3 km) from Mississippi River.

Located in Cape Girardeau, Hampton Inn Cape Girardeau I 55 East is within a 5-minute drive of Saint Francis Medical Center and Saint Francis Healthcare System. This hotel is 3.9 mi (6.2 km) from Shawnee National Forest and 4.3 mi (6.9 km) from Mississippi River.

Located in Cape Girardeau, Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel is in a rural location, within a 5-minute drive of Saint Francis Medical Center and Saint Francis Healthcare System. This spa hotel is 4.2 mi (6.7 km) from Shawnee National Forest and 4.5 mi (7.2 km) from Mississippi River.

Located in Jackson, Town House Inn is a 4-minute drive from Litz Park and 7 minutes from Cape Girardeau Conservation Nature Center. This motel is 9.8 mi (15.8 km) from Shawnee National Forest and 10.1 mi (16.2 km) from Mississippi River.

When you stay at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau in Jackson, you'll be in the business district, within a 5-minute drive of Cape Girardeau Conservation Nature Center and Saint Francis Healthcare System. This hotel is 6.6 mi (10.6 km) from Shawnee National Forest and 6.9 mi (11.1 km) from Mississippi River.