The Gran Cruz House is in the perfect location, and the team there is amazing. We loved our stay and would definitely stay there again. It is simple to take the water taxi across the river to visit the port houses, and the area around the hotel is very walkable and lively, with lots of restaurants and bars. I would have liked to have had a coffee pot or tea kettle in the room, but it was pretty simple to go outside and find coffee, so that is a pretty minor quibble.
It was nice being greeted with port, and the breakfast was excellent.