Great Hotel!
My wife and I stayed at Hotel Sant'Anna over Easter weekend 2026. The staff was fantastic. They knew the area, suggested some do's and don'ts, and we most helpful when our flight home was canceled - rebooking us around the corner.
The room was clean, everything worked, and was most comfortable.
The breakfast area was clean, attendants were perfect, and the buffet had something for every taste.
Location is 2.5 minutes from San Pietro. Great for a nighttime gelato, quick walk around the square, then home to rest.
I would HIGHLY recommend this hotel for anyone staying in the Vatican area.
The only negative was not under their control. The weather was unseasonably warm, but the hotel was not allowed to run the air conditioning due to government regulations. With that, we needed to open our windows overnight to get some cool air. The restaurants along the street have outside seating, and when they close, the restaurant staff is not very quiet as they drag their chairs and tables back inside, and conversing using "outside voices" along the way. It only lasted about 30 minutes, but after 11pm when you've been walking for 8 hours all day, you want quiet when you sleep. But, that was just because of the lack of being allowed to run AC. The one night we kept the windows closed, it was quiet and easy to sleep. This is not a complaint about the hotel. The warm weather was very welcome, and the noise was a small price to pay. :-)
